IPS EXOSOME iPS exosome therapy

The latest in regenerative medicine, born from iPS cells

In recent years, a groundbreaking treatment that has been attracting attention in the field of regenerative medicine is iPS exosome therapy.
This brings out the body's innate healing power and addresses a wide range of concerns, including joint pain, skin aging, and chronic fatigue.

"I want to improve the pain from the root"
"I want to have a body that doesn't get tired easily"
"I want to restore firmness to my skin"

iPS exosome therapy offers new possibilities for such aspirations.

What are iPS exosomes?

iPS exosomes are exosomes produced from iPS cells.

Exosomes are tiny sacs, 50 to 150 nanometers in diameter, secreted by cells and function as "messengers" that carry messages between cells. They contain substances that suppress inflammation and repair tissue. When administered into the body via injection or intravenous drip, they can have the effect of relieving joint pain, rejuvenating skin, and improving fatigue.

Exosome therapy is a type of regenerative medicine similar to stem cell therapy, but it differs significantly in that it uses substances secreted by cells rather than the cells themselves. This makes it extremely safe, with an extremely low risk of rejection or tumor formation.

Regular exosomes are produced from adult fat and bone marrow cells, so the cells of a 70-year-old person will only produce exosomes with the strength appropriate for a 70-year-old. However, iPS exosomes are produced from special cells called iPS cells (induced pluripotent stem cells).

iPS cells are special cells created from skin and blood cells, and thanks to a technology developed by Professor Shinya Yamanaka of Kyoto University, for which he received a Nobel Prize, they are revolutionary cells that can rejuvenate even the cells of an 80-year-old person to the youthful state of a baby. iPS exosomes created from these "rejuvenated cells" consistently demonstrate a high level of repair, regardless of age.

Myths and truths about exosomes

While there are certainly negative opinions about exosomes, many of these are related to low-quality products. Properly produced exosomes can be expected to have definite benefits.

Differences in quality lead to differences in effectiveness

When producing exosomes, a purification process is required to select only particles of a specific size from cell culture fluid (bio-fluid) and remove unnecessary components.
However, some of the products on the market

Insufficient purification: Simply centrifuging the mixture can contaminate waste and unnecessary components.

Uses cells of unknown origin: It is unknown what cells it was made from and what it contains.

Inadequate quality control: Insufficient infectious disease and purity tests

These low-quality products may not only fail to produce the desired results, but may also have negative side effects.

Characteristics of our iPS exosome treatment

1 Uses the highest quality iPS exosomes

In order to maximize the effectiveness of our treatment, we use iPS exosomes from ReproCELL, which are manufactured under strict quality control.

The quality of exosome products is directly linked to the effectiveness of treatment. There are various quality products on the market, but our clinic ensures the highest level of quality in the following areas:

Manufactured in a facility licensed for the manufacture of specific cell-processed products
Uses regenerative medicine-grade iPS cells from a woman in her 20s as raw material
Safe formulation using medical saline
Highly concentrated exosomes, 20 billion per vial

In other words, our IPS exosomes are the highest quality product currently available, combining all the qualities of youthfulness, safety, and effectiveness.

Our highest quality iPS exosome products

Specific cell processing manufacturing licensed facility
Manufacturing inMedical factory level inspection standards,
Passed national inspection standards
Regenerative medicine grade for women in their 20s
Uses iPS cells as raw materialYoung and healthy cells, maximum repair ability
Medical saline solution
Safe formulation
20 billion per vial
Highly concentrated exosomes2 to 10 times the amount of a single product

2 Flexible administration

Although IPS exosomes can be expected to be effective on their own, our hospital will propose the optimal administration method depending on the patient's symptoms and goals.
Your doctor will recommend the best combination for you based on your examination and test results.

METHOD

1 When used alone

Those who wish to see early improvement in symptoms
Those who want to start with exosome therapy
Those considering combining with other treatments

2 In the case of combination therapy

Our clinic offers a two-stage treatment based on the body's natural repair process (macrophage treatment → stem cell treatment), and IPS exosomes can be used flexibly within this process.

Combined use with macrophage therapy: Enhances anti-inflammatory effects.

Combined use with stem cell therapy: It activates intercellular communication and maximizes repair effects.

Maintenance after treatment: Use regularly to maintain and improve effectiveness.

3 Symptom-specific administration method

METHOD

1 Local injection (pinpoint treatment)

By delivering exosomes directly to areas of inflammation or damage, it promotes efficient repair.

Intra-articular injection

Directly addressing knee, shoulder, and hip pain

Improvement of osteoarthritis
Recovery from sports-related joint injuries
Options for those who want to avoid surgery

Subcutaneous injection

Skin rejuvenation, wrinkle and sagging improvement

Promotes skin cell regeneration
Improved skin texture and firmness
Improve wrinkles and sagging

Scalp injection

Improves thinning hair and hair loss

Activation of hair follicles
Improved hair quality

2 Infusion therapy

It can cover both the effects on the skin and the effects on the joints.
Recommended for those with multiple concerns

3 Nasal administration (direct approach to the brain)

It is effective in preventing dementia, improving brain function, and improving sleep quality.
It is attracting attention as a new approach to neurodegenerative diseases.

*At our hospital, exosomes are delivered to the target area more effectively by local administration rather than intravenous administration.

DISEASE Regenerative medicine targets
Symptoms and diseases

Orthopedics and joint diseases

Low back pain
arthritis
Spinal canal stenosis
Osteoarthritis of the knee
Meniscus damage
Coxarthrosis

Gynecological and endocrine disorders

Menopause

Improves symptoms by adjusting hormone balance and suppressing chronic inflammation
infertility

Improve ovarian function, repair endometrial lining, and improve the body's ability to become pregnant

Sequelae of infectious diseases and immune disorders

Corona aftereffects

Suppresses inflammation throughout the body, normalizes immune function, and improves fatigue and shortness of breath
Chronic fatigue syndrome

Improved energy production at the cellular level, alleviating symptoms

Internal medicine/metabolic diseases

Diabetes mellitus

Improved pancreatic beta cell function and blood sugar control
Liver disease

Regeneration of liver cells and recovery of liver function
Kidney disease

Protecting and improving kidney function

Nervous system disorders

Stroke sequelae

Regeneration of nerve cells, improvement of paralysis and numbness
Spinal cord injury

Recovery of nerve function, improvement of motor function
Parkinson's disease

Neuroprotection, suppression of symptom progression

cardiovascular disease

Myocardial infarction

Regeneration of cardiomyocytes and improvement of cardiac function
peripheral arterial disease

Angiogenesis, blood flow improvement

Beauty and Anti-Aging

Skin regeneration

Promotes collagen production and improves wrinkles and sagging
hair regeneration

Activation of hair follicles and promotion of hair growth
whole body anti aging

Rejuvenation at the cellular level

*Effects vary from person to person. Appropriateness will be determined through a medical examination.

FLOW Treatment flow

STEP

Detailed examination and testing

Check the detailed condition of the symptoms and receive medical examination
Inflammation levels are measured using inflammatory marker tests (high-sensitivity CRP, IL-1β, IL-6, TNFα)
EpiClock test measures the effects of inflammation on cells
Determining treatment suitability

STEP

Pretreatment (macrophage treatment)

Improves chronic inflammation
Improving the restoration environment
Creating a foundation where stem cells can function

STEP

Stem cell collection and culture

Stem cells are extracted from adipose tissue and bone marrow
Cultivation and quality control in a dedicated clean room
Only cells that meet strict standards are used

STEP

Treatment implementation

Select the most appropriate administration method depending on the symptoms and area (intra-articular injection, intravenous drip, local injection, etc.)
Combination treatment with our unique "Cell Revival®"

STEP

Long-term follow-up

Up to two years of continuous support
Effect measured through regular blood tests
Consider additional treatment if necessary

FAQ Frequently Asked Questions

Please tell me about the safety of iPS exosome therapy. Are there any side effects?

iPS exosome therapy is an extremely safe treatment because it uses substances secreted by cells rather than the cells themselves. Reasons for its safety: - Extremely low risk of rejection: Because exosomes are not cells, there is almost no immune rejection. - No risk of tumor formation: Unlike stem cell therapy, there is no need to worry about cell proliferation. - Strict quality control: Only medical-grade products manufactured in facilities licensed for specific cell processing are used. - Infectious disease testing: All products pass infection testing. Minor side effects: - Mild pain and swelling at the injection site (resolves within a few days) - Rarely, a mild feeling of heat (resolves within 1-2 days) - Temporary fatigue. No serious side effects have been reported to date. In the unlikely event of an adverse reaction, specialists will respond promptly.
What is the difference between regular exosomes and iPS exosomes?

The biggest differences are "youth" and "stable quality." Regular exosomes: - Produced from adult fat or bone marrow - Dependent on the donor's age (cells from a 70-year-old produce exosomes appropriate for a 70-year-old) - Individual quality varies - Quality fluctuates with each collection. iPS exosomes: - Produced from iPS cells (induced pluripotent stem cells) - Because the cells are rejuvenated, they consistently have a high repair effect - Uses regenerative medicine-grade iPS cells from a woman in her 20s - Stable quality and consistent effectiveness. Professor Shinya Yamanaka's Nobel Prize-winning technology allows iPS cells from an 80-year-old to function effectively. These iPS exosomes, produced from "age-appropriate cells," are expected to be effective.
What symptoms does it treat? Will it improve my symptoms?

iPS exosome therapy can treat a wide range of conditions through both inflammation suppression and tissue repair. Particularly effective conditions: Joint and orthopedic conditions: - Osteoarthritis, arthritis - Back pain, stiff shoulders - Sports injuries - Joint pain where surgery is desired Beauty and anti-aging: - Improved skin firmness and radiance - Reduced wrinkles and sagging - Improved thinning and hair loss Systemic conditions: - Chronic fatigue, lethargy - Menopausal symptoms - Poor sleep quality - Prevention of cognitive decline Other: - Aftereffects of COVID-19 - Diabetes, liver dysfunction - Neurological disorders The optimal administration method will be selected and treatment will be administered based on the patient's symptoms. The appropriate treatment will be determined through an initial consultation.
I've seen exosome therapy at other clinics, but what's the difference?

Our iPS exosome therapy offers three key differences. 1. We use the highest quality iPS exosomes. While conventional exosomes are derived from adult cells and vary in quality, ours are consistently high-quality, using 20 billion exosomes per vial. 2. Our unique combination therapy, "Cell Revival®," offers the following benefits: Other clinics administer exosomes alone; our clinic can combine them with macrophage therapy and stem cell therapy. By administering exosomes after correcting the internal environment, we maximize effectiveness. 3. Visualization of results and long-term follow-up: Other clinics only subjectively evaluate results; our clinic quantifies results with inflammatory marker testing and provides up to two years of follow-up. While there are products on the market that use insufficiently purified or cells of unknown origin, our clinic uses only safe formulations created by iPS cell experts.
Please tell me about the number of treatments, duration, and cost.

For more information, please see "Prices and Treatment Plans."

View Frequently Asked Questions and Answers

Clinic Le GINZA
5 features

Treating aging as a therapeutic target
New regenerative medicine

The aim is to scientifically measure and improve chronic inflammation, a treatable cause of ailments that have traditionally been attributed to aging (an approach to scientifically diagnosing and treating aging).