MACROPHAGE Macrophage treatment

Our unique treatment that enhances the effectiveness of stem cell therapy

We often hear people say, "I underwent stem cell therapy, but I didn't see the changes I expected."

In fact, one of the reasons for this is that chronic inflammation reduces the function of macrophages (immune cells).

At our clinic, we combine stem cell therapy with treatments that regulate macrophage function to ensure that stem cells can fully promote recovery. This improves the inflammatory environment in the body and creates a foundation for stem cells to exert their true potential.

Clinic Le GINZA is
The only clinic in Japan that offers macrophage treatment*.

*As of September 2025

What are macrophages?

Macrophages are a type of immune cell that protects our bodies.
They are a type of white blood cell and are known as "cleaners" that deal with bacteria, viruses, broken cells, and other invading bacteria in the body.
However, the true importance of macrophages lies in their ability to transform beyond mere cleaning roles into "repair support" roles.

This "switching" of roles is key to the body's ability to heal properly.

The two roles of macrophages

Cleaner (M1 type): Removes bacteria and broken cells from inflamed areas

Repair support role (M2 type): Promotes tissue repair and supports stem cell function

How do macrophages function in a healthy body?

When our body is injured or inflamed, it repairs itself in the following sequence shown in the diagram. Macrophages play an important role in this process.

However, in the presence of chronic inflammation, this switch is disrupted, and macrophages become stuck in their cleaning role, stalling the repair process.

As a result,

Recovery steps not progressing
Chronic inflammation
Chronic pain and discomfort
Repeated treatments only result in temporary improvement

In other words, no matter how excellent the regenerative ability of stem cells is, recovery will not begin in earnest unless the body's environment is in good condition.

The body's repair mechanism

Inflammation occurs(Indicate the damaged area)
Stops bleeding(Platelets seal the wound)
Macrophages
Cleaning up broken cells and bacteria
Macrophages replace the cleaning role
Switch to repair support role
This is importantStem cells create new tissue(Stem cells gather from various places)
Cells cooperate with each other(Information exchange through exosomes)
Completely healed(Tissue regeneration completed)

Macrophage therapy lays the foundation for recovery
Arrange

The body's natural recovery always begins with "environmental improvement." The natural flow is for "tissue regeneration" to proceed on top of that.
However, in conventional treatments, stem cells are often administered when chronic inflammation is ongoing.
In this case, stem cells focus on suppressing inflammation and are unable to fully exert their natural healing power.

If the foundation is not in place

Stem cells use energy to fight inflammation
Unable to focus on repairs
Playback ability is not fully utilized

Once the foundation is in place

Stem cells can focus on recovery
Provides necessary nutrients and oxygen
Stem cells also function more smoothly

Our treatments follow a process that follows the body's natural healing process.

Stage1 Macrophage treatment
(Environmental Improvement)

Regulate chronic inflammation
Switching macrophages to a repair support role
Creating an environment where stem cells can function

Stage2 Stem cell therapy (full-scale tissue regeneration)

Injecting stem cells into the prepared environment
Stem cells dedicated to recovery
Sustained improvement can be expected over 1-2 years

This is the body's natural recovery process.
First, by preparing the right "field," stem cells can exert their maximum potential.

DISEASE Stem cell therapy and regenerative medicine target
Symptoms and diseases

Orthopedics and joint diseases

Low back pain
arthritis
Spinal canal stenosis
Osteoarthritis of the knee
Meniscus damage
Coxarthrosis

Gynecological and endocrine disorders

Menopause

Improves symptoms by adjusting hormone balance and suppressing chronic inflammation
infertility

Improve ovarian function, repair endometrial lining, and improve the body's ability to become pregnant

Sequelae of infectious diseases and immune disorders

Corona aftereffects

Suppresses inflammation throughout the body, normalizes immune function, and improves fatigue and shortness of breath
Chronic fatigue syndrome

Improved energy production at the cellular level, alleviating symptoms

Internal medicine/metabolic diseases

Diabetes mellitus

Improved pancreatic beta cell function and blood sugar control
Liver disease

Regeneration of liver cells and recovery of liver function
Kidney disease

Protecting and improving kidney function

Nervous system disorders

Stroke sequelae

Regeneration of nerve cells, improvement of paralysis and numbness
Spinal cord injury

Recovery of nerve function, improvement of motor function
Parkinson's disease

Neuroprotection, suppression of symptom progression

cardiovascular disease

Myocardial infarction

Regeneration of cardiomyocytes and improvement of cardiac function
peripheral arterial disease

Angiogenesis, blood flow improvement

Beauty and Anti-Aging

Skin regeneration

Promotes collagen production and improves wrinkles and sagging
hair regeneration

Activation of hair follicles and promotion of hair growth
whole body anti aging

Rejuvenation at the cellular level

*Effects vary from person to person. Appropriateness will be determined through a medical examination.

FLOW Treatment flow

STEP

Detailed examination and testing

Check the detailed condition of the symptoms and receive medical examination
Inflammation levels are measured using inflammatory marker tests (high-sensitivity CRP, IL-1β, IL-6, TNFα)
EpiClock test measures the effects of inflammation on cells
Determining treatment suitability

STEP

Pretreatment (macrophage treatment)

Improves chronic inflammation
Improving the restoration environment
Creating a foundation where stem cells can function

STEP

Stem cell collection and culture

Stem cells are extracted from adipose tissue and bone marrow
Cultivation and quality control in a dedicated clean room
Only cells that meet strict standards are used

STEP

Treatment implementation

Select the most appropriate administration method depending on the symptoms and area (intra-articular injection, intravenous drip, local injection, etc.)
Combination treatment with our unique "Cell Revival®"

STEP

Long-term follow-up

Up to two years of continuous support
Effect measured through regular blood tests
Consider additional treatment if necessary

FAQ Frequently Asked Questions

What is macrophage therapy and why is it needed?

Macrophage therapy is a pretreatment treatment offered exclusively at our clinic in Japan (as of August 2025) to maximize the effectiveness of stem cell therapy. Macrophages: - A type of immune cell in the body - Normally, they act as "cleaners" to remove bacteria and damaged cells - In a healthy body, they switch to a "repair support" role, promoting tissue regeneration. Why is it necessary?: When chronic inflammation is present, macrophages remain fixed in their "cleaner" role and are unable to switch to a "repair support" role. As a result, even if stem cells are administered, the treatment is ineffective. Macrophage therapy promotes this switch, creating an environment in which stem cells can function at their full potential. As a result, symptoms may improve with macrophage therapy alone.
Why can't I get macrophage therapy at other regenerative medicine clinics?

Macrophage therapy requires special techniques and expertise. Reasons why only our clinic can offer it: 1. Exclusive contract: Treatment using techniques under an exclusive contract with an overseas institution 2. Treatment by specialists: A team of doctors well versed in macrophage therapy 3. Special culture techniques: Techniques for properly adjusting macrophages 4. Comprehensive treatment system: Systematized as Cell Revival® While other clinics generally only offer stem cell therapy, our clinic achieves even greater therapeutic effects by combining it with macrophage therapy as a pre-treatment.
What are the specific treatment methods and duration of macrophage therapy?

Macrophage therapy involves cultivating and adjusting macrophages collected from the patient's blood and returning them to the body. Treatment procedure: 1. Blood collection. 2. Macrophage isolation and cultivation (2-3 weeks). 3. Functional adjustment: From M1 type (cleaning role) to M2 type (repair support role). 4. Administration: Infusion or local injection. Treatment period: 2-4 weeks after blood collection, administered in 1-3 divided doses depending on symptoms. After macrophage therapy is completed, the patient will transition to stem cell therapy. The period will be adjusted depending on the degree of chronic inflammation.
Are there any side effects to macrophage therapy? Can it be taken alone?

Side effects: Macrophage therapy uses your own cells, so there are very few serious side effects. Minor side effects: - Mild pain or internal bleeding at the blood collection site - Mild feeling of heat after administration (resolves in 1-2 days) - Temporary swelling (joints) About standalone treatment: Macrophage therapy can be performed on its own. It is especially recommended for the following: - Those with severe chronic inflammation - Those who have undergone stem cell therapy at another hospital but have not seen satisfactory results - Those who want to first improve their internal environment However, to achieve maximum results, we recommend combining it with subsequent stem cell therapy (Cell Revival®).
How can the effectiveness of macrophage therapy be confirmed?

At our clinic, we not only check for changes in symptoms, but also scientifically quantify the effectiveness of treatment. Effectiveness Measurement Methods: 1. Chronic Inflammation Test - Changes in CRP, IL-1β, IL-6, and TNFα - Confirm reduction in inflammation levels before and after treatment 2. Improvement in Clinical Symptoms - Pain Reduction (Evaluated Using a Visual Analogue Scale) - Fatigue Improvement - Improved Sleep Quality 3. Immune Function Test - Macrophage Function Assessment - Improvement in M1/M2 Balance Time to See Results: - After 2-3 weeks: Improvement in inflammatory markers - After 1 month: Subjective symptoms begin to improve - After 2-3 months: Sustained improvement Regular testing allows us to verify the effectiveness of treatment with objective data, eliminating any concerns you may have about whether the treatment is truly working.

View Frequently Asked Questions and Answers

Clinic Le GINZA
5 features

Treating aging as a therapeutic target
New regenerative medicine

The aim is to scientifically measure and improve chronic inflammation, a treatable cause of ailments that have traditionally been attributed to aging (an approach to scientifically diagnosing and treating aging).